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4 Days ago. · Ivo Neto. Express VPN Key. Ivo Neto. Express VPN Patch 7.7.11.4 Crack.Antagonism of the antinociceptive effects of indomethacin, diclofenac and flurbiprofen by CYP2C11 inhibitors in mice.
In this study, the possible role of cytochrome P450 (CYP)2C11 in the antinociceptive effects of three NSAIDs was investigated in male ICR mice. In an acute hot-plate test, indomethacin significantly and dose-dependently (maximal inhibition at 60 mg/kg) increased the reaction time, while diclofenac (maximal inhibition at 30 mg/kg) and flurbiprofen (maximal inhibition at 30 mg/kg) had no effect. The co-administration of aceruloplasmin, an inhibitor of CYP2C11, with indomethacin (60 mg/kg) abolished the effects of indomethacin, while the CYP2C11 inhibitor, miconazole (25 mg/kg), reduced the effect of flurbiprofen but not that of diclofenac. The administration of miconazole (10 mg/kg) or aceruloplasmin (60 mg/kg) with indomethacin
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