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I have and installed Astro Office 2011, but Office 2010 is not listed as an option. Only Office 2003 and Office 2007 are listed. Is there any way to install Office 2010?Chronic renal failure is one of the most frequent complications in patients with systemic lupus erythematosus (SLE). Strikingly, SLE is also the most common primary cause of end stage renal disease (ESRD) in the United States. The incidence of renal involvement in SLE is 50% in patients with renal lupus and 20-25% in SLE patients. The mechanism(s) of renal injury in SLE remains unresolved, but vasculitis in the kidney is one of the important factors. A recent study in our laboratory showed that the temporal expression of cutaneous epitheliotropic T-cell associated chemokines (EL-CKs) and their receptors (CRTh) in SLE was upregulated in lesions of renal lupus and in renal biopsy specimens from SLE patients. In the same study, immunohistochemical staining showed that EL-CKs and CRTh were expressed by infiltrating T cells, vascular endothelial and vascular smooth muscle cells in the lesions. Recombinant EL-CKs could dose-dependently induce leukocyte extravasation and cytokine secretion by endothelial cells. This study therefore suggests that EL-CKs/CRTh play a role in SLE kidney injury, especially in vasculitis. However, in vivo evidence of EL-CKs and their receptors in renal SLE has not been provided. In this proposal, we plan to study the role of EL-CKs and their receptors in SLE kidney lesions by utilizing a well characterized murine model of SLE. 1) To establish that EL-CKs/CRTh have a critical role in SLE kidney lesions and the manifestations of proteinuria and arteritis/vasculitis in an animal model of SLE. IL-2Ralpha-/- mice immunized with human IgG(4) immune complexes will be studied. We will determine whether blocking the EL-CKs or their receptors with a specific antibody can prevent kidney injury, proteinuria and vasculitis. 2) To determine whether EL-CKs and/or their receptors could serve as a clinical marker for kidney injury in SLE patients. EL-CKs and CRTh expression in renal biopsy specimens from SLE c6a93da74d